Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism

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Auto-reactive B cells against peripheral antigen, desmoglein 3, escape from tolerance mechanism.

To examine the mechanism of B cell tolerance against natural peripheral self-antigen, we generated transgenic mice expressing IgM specific for desmoglein 3 (Dsg3) from AK7 monoclonal antibody which itself does not induce blisters. Dsg3 is mainly expressed on stratified squamous epithelium and is the target antigen of an autoimmune bullous disease, pemphigus vulgaris. Transgenic B cells reactive...

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ژورنال

عنوان ژورنال: International Immunology

سال: 2004

ISSN: 1460-2377

DOI: 10.1093/intimm/dxh150